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Elise M. Weerts, Gary S. Wand, Hiroto Kuwabara, Xiaoqiang Xu, J. James Frost, Dean F. Wong and Mary E. McCaul Association of smoking with μ-opioid receptor availability before and during naltrexone blockade in alcohol-dependent subjects Addiction Biology 19

Article first published online: 18 DEC 2012 | DOI: 10.1111/adb.12022

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The current study examined whether severity of tobacco use and nicotine dependence is associated with mu-opioid receptor binding in 25 abstinent alcohol dependent (AD) subjects who completed [11C]carfentanil (CFN) Positron Emission Tomography (PET) imaging before and during treatment with naltrexone under an inpatient protocol. Higher cigarettes/day, nicotine dependence and craving were associated with lower basal CFN binding potential (BPND) across mesolimbic regions. This negative association was maintained during naltrexone treatment for nicotine dependence and cigarettes/day, but not for nicotine craving.

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