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James P. Kesby, David T. Hubbard, Athina Markou and Svetlana Semenova Expression of HIV gp120 protein increases sensitivity to the rewarding properties of methamphetamine in mice Addiction Biology 19

Article first published online: 18 DEC 2012 | DOI: 10.1111/adb.12023

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Methamphetamine abuse and human immunodeficiency virus (HIV) infection induce neuropathological changes in corticolimbic brain areas involved in reward and cognitive function. The HIV/gp120 protein induces neurodegeneration in mice, similar to HIV-induced pathology in humans. Gp120-expressing mice exhibited greater preference for methamphetamine and developed methamphetamine-induced conditioned place preference at lower methamphetamine doses compared with control mice. These data suggest that HIV-positive individuals may have increased sensitivity to methamphetamine, leading to high methamphetamine abuse potential in this population.

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