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Jeffrey A. Simms, Carsten K. Nielsen, Rui Li and Selena E. Bartlett Intermittent access ethanol consumption dysregulates CRF function in the hypothalamus and is attenuated by the CRF-R1 antagonist, CP-376395 Addiction Biology 19

Article first published online: 30 JAN 2013 | DOI: 10.1111/adb.12024

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Corticotrophin-releasing factor (CRF) mediates stress responses and plays a role in ethanol-mediated behaviors. We show that the CRF receptor 1 (CRF-R1) antagonist, CP-376395 reduces 20% ethanol consumption in animals trained to consume ethanol using intermittent, but not using continuous schedule of access. We also show that CRF-mediated G-protein signaling in the hypothalamus of the intermittent drinkers is decreased when compared to controls suggesting an extrahypothalamic mechanism of action. This suggests CRF-R1 antagonists may be valid treatments for alcohol use disorders.

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