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Paola Devoto, Giovanna Flore, Pierluigi Saba, Valentina Bini and Gian Luigi Gessa The dopamine beta-hydroxylase inhibitor nepicastat increases dopamine release and potentiates psychostimulant-induced dopamine release in the prefrontal cortex Addiction Biology 19

Version of Record online: 7 JAN 2013 | DOI: 10.1111/adb.12026

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Inhibition of dopamine-β-hydroxylase suppresses cocaine self-administration reinstatement in rats. Pre-treatment with the selective inhibitor nepicastat decreased noradrenaline outflow induced by cocaine and amphetamine in the medial prefrontal cortex and in the nucleus accumbens, and dramatically potentiated dopamine outflow in the medial prefrontal cortex, but not in the nucleus accumbens. The effect on cortical dopamine level was mimicked by α2adrenergic antagonist administration and reverted by α2adrenergic agonist. The data suggest that noradrenaline tonically inhibit dopamine release in the medial prefrontal cortex.

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