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Albert Batalla, Carles Soriano-Mas, Marina López-Solà, Marta Torrens, José A. Crippa, Sagnik Bhattacharyya, Laura Blanco-Hinojo, Ana B. Fagundo, Ben J. Harrison, Santiago Nogué, Rafael de la Torre, Magí Farré, Jesús Pujol and Rocío Martín-Santos Modulation of brain structure by catechol-O-methyltransferase Val158Met polymorphism in chronic cannabis users Addiction Biology 19

Version of Record online: 14 JAN 2013 | DOI: 10.1111/adb.12027

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Neuroimaging studies have shown that chronic cannabis use may result in structural brain alterations. We measured the influence of the catechol-O-methyltransferase(COMT) genotype on the volume of four key brain regions in 29 early-onset chronic cannabis users and 28 matched non-using controls. The COMT variants influenced the volume of the bilateral ventral caudate nucleus and the left amygdala in both groups in opposite directions. Our findings support reports of neuroanatomical changes associated with cannabis use and, for the first time, reveal that these changes may be influenced by the COMT genotype.

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