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Somayeh Ahmadiantehrani, Segev Barak and Dorit Ron GDNF is a novel ethanol-responsive gene in the VTA: implications for the development and persistence of excessive drinking Addiction Biology 19

Article first published online: 9 JAN 2013 | DOI: 10.1111/adb.12028

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Glial cell line-derived neurotrophic factor (GDNF) is a potent inhibitor of ethanol consumption and relapse. We tested whether ethanol alters GDNF expression to determine how the endogenous growth factor may regulate ethanol consumption. We found that ethanol-mediated upregulation of GDNF during early drinking experiences protects against the development of excessive consumption. Chronic cycles of excessive consumption and withdrawal lowers basal levels of GDNF, suggesting a break down in this protective homeostatic response that contributes to the development of excessive consumption.

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