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Daniel M. Krall, Stephanie L. Lim, Abby M. Cooper, Paul W. Burleson, Derek J. Rhoades, Stephen J. Jacquemin, Daryl C. Willmore, F. Martin Spears and Catherine B. Willmore Withdrawal effect of chronic amphetamine exposure during adolescence on complex maze performance Addiction Biology 19

Version of Record online: 3 FEB 2013 | DOI: 10.1111/adb.12029

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National survey data suggest a steady increase in the diagnosis of Attention Deficit/Hyperactivity Disorder (ADHD). As most children with ADHD take stimulant drugs, these experiments involved administration of 7.5 mg/kg, s.c. amphetamine to rodent subjects throughout adolescence followed by tests using a Stone 14-unit multiple T-maze. Results reveal amphetamine-treated subjects committed fewer major errors and had a significantly lower mean completion time. These findings suggest pharmacotherapy aimed at adolescent-phase treatment of ADHD does not provoke spatial memory deficits after drug withdrawal.

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