Mariusz Sacharczuk, Anna Lesniak, Andrzej W. Lipkowski, Michal Korostynski, Ryszard Przewlocki and Bogdan Sadowski Association between the A107V substitution in the δ-opioid receptors and ethanol drinking in mice selected for high and low analgesia Addiction Biology 19
The opioid system plays an important role in the development of ethanol addiction in mouse lines bred for high (HA) and low (LA) stress-induced analgesia. A C320T mutation in the δ-opioid receptor leads to higher ethanol preference in CT than CC mice under chronic stress. Ethanol preference was much more pronounced in the LA line with decreased opioid system activity. Our results suggest that the δ-opioid receptor is involved in stress enhanced vulnerability to alcohol abuse and dependence.
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