Jérôme Jeanblanc, Fabien Coune, Béatrice Botia and Mickaël Naassila Brain-derived neurotrophic factor mediates the suppression of alcohol self-administration by memantine Addiction Biology 19
We hypothesized that memantine, a non-competitive antagonist of the NMDA receptors, could decrease ethanol consumption in rats via the activation of the BNDF signalling pathway. We found that memantine decreases self-administration and motivation to consume EtOH 6 hrs and 30 hrs post-injection. Furthermore inhibition of the BDNF receptor TrkB only blocks the early memantine-induced decrease in EtOH consumption. These results provide strong evidences showing that memantine, acting via a BDNF-dependent mechanism, might represent a potential treatment for AUDs.
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