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D. K. Reichenbach, Q. Li, R. A. Hoffman, A. L. Williams, W. D. Shlomchik, D. M. Rothstein, A. J. Demetris and F. G. Lakkis Allograft Outcomes in Outbred Mice American Journal of Transplantation 13

Article first published online: 11 JAN 2013 | DOI: 10.1111/ajt.12056

Transplantation of heart allografts between outbred and inbred mice reveals a donor-dependent early graft injury phenotype mediated by complement and neutrophils, but also shows that outbred recipients are not resistant to allograft acceptance, and suggests that mechanisms other than inbreeding depression likely account for the relative ease of inducing tolerance in inbred mice.

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