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L. A. Borthwick, P. A. Corris, R. Mahida, A. Walker, A. Gardner, M. Suwara, G. E. Johnson, E. J. Moisey, M. Brodlie, C. Ward, J. D. Perry, A. De Soyza, D. A. Mann and A. J. Fisher TNFα From Classically Activated Macrophages Accentuates Epithelial to Mesenchymal Transition in Obliterative Bronchiolitis American Journal of Transplantation 13

Article first published online: 17 JAN 2013 | DOI: 10.1111/ajt.12065

This study demonstrates that TNFα released from classically activated macrophages can accentuate TGF-β1-driven epithelial to mesenchymal transition in bronchial epithelial cells isolated from lung transplant patients and that anti-TNFα treatment improves forced expiratory volume in 1 second and 6 minute walk distances in a pilot therapeutic intervention in patients with bronchiolitis obliterans syndrome. See editorial by Neujahr on page 537

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