P. H. Lemaître, B. Vokaer, L.-M. Charbonnier, Y. Iwakura, K. A. Field, M. Estenne, M. Goldman, O. Leo, M. Remmelink and A. Le Moine Cyclosporine A Drives a Th17- and Th2-Mediated Posttransplant Obliterative Airway Disease American Journal of Transplantation 13
Version of Record online: 17 JAN 2013 | DOI: 10.1111/ajt.12067
This study demonstrates that cyclosporine a treatment unbalances T helper alloreactivity and favors Th2 and Th17 as coexisting pathways mediating chronic rejection of heterotopic tracheal allografts.
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