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M.-L. del Rio, P. Schneider, C. Fernandez-Renedo, J.-A. Perez-Simon and J.-I. Rodriguez-Barbosa LIGHT/HVEM/LTβR Interaction as a Target for the Modulation of the Allogeneic Immune Response in Transplantation American Journal of Transplantation 13

Article first published online: 28 JAN 2013 | DOI: 10.1111/ajt.12089

This review discusses how targeting the interaction of LIGHT with HVEM and/or LTbR using recombinant soluble decoy receptors or monoclonal antibodies may represent an innovative therapeutic intervention for the prevention and treatment of allograft rejection and promotion of donor-specific tolerance.

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