M. B. van Werkhoven, J. Damman, M. C. R. F. van Dijk, M. R. Daha, I. J. de Jong, A. Leliveld, C. Krikke, H. G. Leuvenink, H. van Goor, W. J. van Son, P. Olinga, J.-L. Hillebrands and M. A. J. Seelen Complement Mediated Renal Inflammation Induced by Donor Brain Death: Role of Renal C5a-C5aR Interaction American Journal of Transplantation 13
Article first published online: 7 FEB 2013 | DOI: 10.1111/ajt.12130
Using a precision-cut human kidney slice system, these data suggest that systemic generation of C5a in combination with increased renal C5aR expression in brain-dead donors mediates local renal infl ammation in braindead donor grafts via tubular C5a-C5aR interaction.
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