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S. Iida, T. Suzuki, K. Tanabe, A. Valujskikh, R. L. Fairchild and R. Abe Transient Lymphopenia Breaks Costimulatory Blockade-Based Peripheral Tolerance and Initiates Cardiac Allograft Rejection American Journal of Transplantation 13

Article first published online: 4 SEP 2013 | DOI: 10.1111/ajt.12342

Induction of lymphopenia at day 60 posttransplant in recipients carrying long-term surviving cardiac allografts stimulates the generation of donor-reactive effector-memory T cells that break the tolerance and reject the allograft.

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