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P. Cravedi, J. Leventhal, P. Lakhani, S. C. Ward, M. J. Donovan and P. S. Heeger Immune Cell-Derived C3a and C5a Costimulate Human T Cell Alloimmunity American Journal of Transplantation 13

Version of Record online: 6 SEP 2013 | DOI: 10.1111/ajt.12405

This study shows that APC-derived C3a and C5a transmit costimulatory, proliferative signals upon ligating their receptors expressed on human alloreactive CD4 T cells, and that pharmacological C5a receptor blockade reduces human, T cell-mediated, xenogeneic graft versus host disease in vivo.

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