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W.-Q. Li, J.-L. Han, M.-F. Zhang and A.A. Qureshi Interactions between adiposity and genetic polymorphisms on the risk of psoriasis British Journal of Dermatology 168

Version of Record online: 28 FEB 2013 | DOI: 10.1111/bjd.12001

What’s already known about this topic?

  •  Adiposity has been associated with psoriasis in a prospective study and the chronic, low-grade inflammatory state associated with adiposity has been postulated as the key underlying mechanism.
  •  Prior genome-wide association studies (GWAS) have identified a number of genes associated with risk of psoriasis, with IL12B and IL23R demonstrating the most consistent associations across multiple studies.
  •  Evidence on the gene–environment interactions in psoriasis has been very sparse.

What does this study add?

  •  In a post-GWAS approach, we confirmed the elevated risk of psoriasis associated with the rs3212227 single-nucleotide polymorphism in IL12B, but only among overweight individuals.
  •  The association between a polymorphism in IL12B and psoriasis risk may be modified by measures of overall and central adiposity.
  •  Our study indicated that gene–environment interaction could play an important role in the development of psoriasis.

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