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G.A. Bin Saif, A. McMichael, S.G. Kwatra, Y.-H. Chan and G. Yosipovitch Central centrifugal cicatricial alopecia severity is associated with cowhage-induced itch British Journal of Dermatology 168

Version of Record online: 30 JAN 2013 | DOI: 10.1111/bjd.12043

What’s already known about this topic?

  • Patients with central centrifugal cicatricial alopecia (CCCA) often complain of intense itch, pain and burning sensations. However, the neural component of these skin sensations has not been assessed.

What does this study add?

  • This study demonstrates a significant correlation between cowhage-induced itch intensity and the severity of CCCA.
  • As cowhage signals through the protease-activated receptor (PAR)-2, these results suggest a putative role for the PAR-2 pathway in CCCA-associated skin sensation. Examining for itch and other dysaesthesias in patients with CCCA is of vital importance to dermatologists in assessing disease severity.

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