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A. Hald, R.M. Andrés, M.L. Salskov-Iversen, R.B. Kjellerup, L. Iversen and C. Johansen STAT1 expression and activation is increased in lesional psoriatic skin British Journal of Dermatology 168

Version of Record online: 30 JAN 2013 | DOI: 10.1111/bjd.12049

What’s already known about this topic?

  •  The expression of STAT1 is increased in lesional psoriatic skin.
  •  STAT1 has an increased nuclear expression in psoriatic epidermis.
  •  STAT1 can be phosphorylated on two different phosphorylation sites: a tyrosine 701 site and a serine 727 site.
  •  STAT1 is involved in the regulation of interferon-responsive genes.

What does this study add?

  •  The phosphorylation level of STAT1(Tyr701) and STAT1(Ser727) is increased in lesional psoriatic skin.
  •  The two kinases, p38 mitogen-activated protein kinase and protein kinase C-δ, are involved in the phosphorylation of STAT1 in cultured human keratinocytes.

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