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V. de Giorgi, A. Gori, S. Gandini, F. Papi, M. Grazzini, S. Rossari, A. Simoni, V. Maio and D. Massi Oestrogen receptor beta and melanoma: a comparative study British Journal of Dermatology 168

Version of Record online: 28 FEB 2013 | DOI: 10.1111/bjd.12056

What’s already known about this topic?

• The growing focus on the loss of oestrogen receptor beta (ERβ) expression as a common step in cancer initiation and progression has led researchers to revisit the role of oestrogens and ERs in malignant melanoma, which is still intensely debated.

What does this study add?

  •  There is a statistically significant loss of ERβ protein in melanoma compared with adjacent healthy tissue. The loss is significantly and inversely associated with Breslow thickness.
  •  Our results indicate that loss of the ERβ protein is significantly greater in men than in women.
  •  We investigated the relationship between menopause status and ERβ expression in women with melanoma.

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