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G. Heine, N. Hoefer, A. Franke, U. Nöthling, R.R. Schumann, L. Hamann and M. Worm Association of vitamin D receptor gene polymorphisms with severe atopic dermatitis in adults British Journal of Dermatology 168

Article first published online: 12 MAR 2013 | DOI: 10.1111/bjd.12077

What’s already known about this topic?

  • A role of vitamin D in the pathogenesis of atopic dermatitis (AD) is suggested by epidemiological and experimental data.
  • Genetic variants in the vitamin D receptor gene (VDR) are known, but their presence has not been investigated in patients with AD.

What does this study add?

  • We show that, in patients with severe AD, specific single nucleotide polymorphisms in the VDR gene are significantly over-represented. This implies the need to consider the VDR genotype of probands in vitamin D-related clinical studies examining vitamin D in AD, and the need for further mechanistic research.

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