G. Heine, N. Hoefer, A. Franke, U. Nöthling, R.R. Schumann, L. Hamann and M. Worm Association of vitamin D receptor gene polymorphisms with severe atopic dermatitis in adults British Journal of Dermatology 168
What’s already known about this topic?
A role of vitamin D in the pathogenesis of atopic dermatitis (AD) is suggested by epidemiological and experimental data.
Genetic variants in the vitamin D receptor gene (VDR) are known, but their presence has not been investigated in patients with AD.
What does this study add?
We show that, in patients with severe AD, specific single nucleotide polymorphisms in the VDR gene are significantly over-represented. This implies the need to consider the VDR genotype of probands in vitamin D-related clinical studies examining vitamin D in AD, and the need for further mechanistic research.
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