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M.J. Visser, L. Landeck, L.E. Campbell, W.H.I. McLean, S. Weidinger, F. Calkoen, S.M. John and S. Kezic Impact of atopic dermatitis and loss-of-function mutations in the filaggrin gene on the development of occupational irritant contact dermatitis British Journal of Dermatology 168

Version of Record online: 30 JAN 2013 | DOI: 10.1111/bjd.12083

What’s already known about this topic?

•Filaggrin gene (FLG) loss-of-function mutations increase the risk of developing atopic dermatitis (AD).

It has been reported that FLG mutations are associated with irritant contact dermatitis (ICD); however, it is unclear whether they are an independent risk factor or work through AD.

What does this study add?

FLG mutations are associated with ICD even when adjusted for AD.

• Individuals with concurrent FLG mutations [odds ratio (OR) 1·61] and AD (OR 2·89) are at the highest risk of developing ICD (combined OR 4·7).

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