M.J. Visser, L. Landeck, L.E. Campbell, W.H.I. McLean, S. Weidinger, F. Calkoen, S.M. John and S. Kezic Impact of atopic dermatitis and loss-of-function mutations in the filaggrin gene on the development of occupational irritant contact dermatitis British Journal of Dermatology 168
What’s already known about this topic?
•Filaggrin gene (FLG) loss-of-function mutations increase the risk of developing atopic dermatitis (AD).
It has been reported that FLG mutations are associated with irritant contact dermatitis (ICD); however, it is unclear whether they are an independent risk factor or work through AD.
What does this study add?
•FLG mutations are associated with ICD even when adjusted for AD.
• Individuals with concurrent FLG mutations [odds ratio (OR) 1·61] and AD (OR 2·89) are at the highest risk of developing ICD (combined OR 4·7).
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf