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C. Skobowiat, R.M. Sayre, J.C. Dowdy and A.T. Slominski Ultraviolet radiation regulates cortisol activity in a waveband-dependent manner in human skin ex vivo British Journal of Dermatology 168

Article first published online: 31 JAN 2013 | DOI: 10.1111/bjd.12096

What’s already known about this topic?

  •  Glucocorticoids are widely used in dermatology.
  •  Skin has endocrine functions.
  •  Steroids are produced in the skin.

What does this study add?

  •  Ultraviolet (UV) B and C radiation stimulates the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)/HSD11B1 expression and cortisol production in the skin.
  •  UVB and UVC radiation inhibits epidermal glucocorticoid receptor (GR) expression.
  •  UVA radiation stimulates 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2)/HSD11B2 expression in the skin.
  •  UVA radiation has minor effects on GR expression.
  •  Differential UV wavebands effects on steroidogenesis are to maintain skin homeostasis.

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