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J. Kwok and K.M. Kwong Detection of HLA-B*58:01, the susceptible allele for allopurinol-induced hypersensitivity, by loop-mediated isothermal amplification British Journal of Dermatology 168

Article first published online: 28 FEB 2013 | DOI: 10.1111/bjd.12097

What’s already known about this topic?

  •  Loop-mediated isothermal amplification (LAMP) is a rapid test with shorter hands-on time and assay time than routine genotyping assays.
  •  Routine sequence-specific oligonucleotide and sequence-specific priming assays for HLA-B*58:01 screening have high set-up times and are costly to perform.

What does this study add?

  •  This is the first study using LAMP for the detection of HLA-B*58:01-associated allopurinol-induced hypersensitivity.
  •  DNA samples, rather than blood samples, must be used as the starting materials for LAMP.
  •  LAMP is a cost-effective test for potential allopurinol-induced drug hypersensitivity screening.

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