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A. Savva, T. Kanni, G. Damoraki, A. Kotsaki, S. Giatrakou, I. Grech, A. Katoulis, E. Papadavid and E.J. Giamarellos-Bourboulis Impact of Toll-like receptor-4 and tumour necrosis factor gene polymorphisms in patients with hidradenitis suppurativa British Journal of Dermatology 168

Version of Record online: 30 JAN 2013 | DOI: 10.1111/bjd.12105

What’s already known about this topic?

  •  Hidradenitis suppurativa is a chronic inflammatory skin disorder; immunological dysfunctions and familial predisposition are involved in disease pathogenesis.
  •  Treatment with tumour necrosis factor (TNF) antagonists has shown promising effect in certain studies enrolling a limited number of patients.

What does this study add?

  •  The presence of the −238 polymorphism of the TNF gene is associated with disease susceptibility.
  •  Carriage of single nucleotide polymorphisms of the promoter region of the TNF gene is related to disease severity and unfavourable responses to TNF antagonists.

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