A. Savva, T. Kanni, G. Damoraki, A. Kotsaki, S. Giatrakou, I. Grech, A. Katoulis, E. Papadavid and E.J. Giamarellos-Bourboulis Impact of Toll-like receptor-4 and tumour necrosis factor gene polymorphisms in patients with hidradenitis suppurativa British Journal of Dermatology 168
What’s already known about this topic?
Hidradenitis suppurativa is a chronic inflammatory skin disorder; immunological dysfunctions and familial predisposition are involved in disease pathogenesis.
Treatment with tumour necrosis factor (TNF) antagonists has shown promising effect in certain studies enrolling a limited number of patients.
What does this study add?
The presence of the −238 polymorphism of the TNF gene is associated with disease susceptibility.
Carriage of single nucleotide polymorphisms of the promoter region of the TNF gene is related to disease severity and unfavourable responses to TNF antagonists.
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