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M. Hagiyama, T. Inoue, T. Furuno, T. Iino, S. Itami, M. Nakanishi, H. Asada, Y. Hosokawa and A. Ito Increased expression of cell adhesion molecule 1 by mast cells as a cause of enhanced nerve–mast cell interaction in a hapten-induced mouse model of atopic dermatitis British Journal of Dermatology 168

Version of Record online: 25 MAR 2013 | DOI: 10.1111/bjd.12108

What’s already known about this topic?

  •  Enhanced sensory nerve–skin mast cell interaction is involved in the pathogenesis of atopic dermatitis (AD).

What does this study add?

  •  In a hapten-induced AD mouse model, lesional mast cells were found to express much higher levels of cell adhesion molecule-1 (CADM1) than nonlesional mast cells.
  •  CADM1 on mast cells enhanced sensory nerve–mast cell adhesion and communication in vitro in a dose-dependent manner.
  •  Increased CADM1 expression in mast cells appears to play a role in the pathogenesis of AD.

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