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Y. Yamaguchi, J. Ono, M. Masuoka, S. Ohta, K. Izuhara, Z. Ikezawa, M. Aihara and K. Takahashi Serum periostin levels are correlated with progressive skin sclerosis in patients with systemic sclerosis British Journal of Dermatology 168

Article first published online: 7 MAR 2013 | DOI: 10.1111/bjd.12117

What’s already known about this topic?

  •  Periostin is a matricellular protein known as a modulator of wound healing and fibrosis. However, the role of periostin in the pathogenesis of systemic sclerosis has not been elucidated.

What does this study add?

  •  Periostin is highly expressed in affected skin and serum in patients with systemic sclerosis.
  •  Increased serum periostin levels correlate with the skin fibrosis score, suggesting a possible biomarker of disease severity.

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