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P. Gisondi, V. Lora, C. Bonauguri, A. Russo, G. Lippi and G. Girolomoni Serum chemerin is increased in patients with chronic plaque psoriasis and normalizes following treatment with infliximab British Journal of Dermatology 168

Version of Record online: 27 FEB 2013 | DOI: 10.1111/bjd.12118

What’s already known about this topic?

  •  Chronic plaque psoriasis is frequently associated with obesity, which is a metabolic and inflammatory disorder.
  •  Adipokines are involved in the pathogenesis of psoriasis and they are biomarkers of obesity-related inflammation and cardiovascular risk.
  •  Chemerin is pathogenetically expressed in psoriatic lesional skin.

What does this study add?

  •  Patients with psoriasis have higher blood levels of adipokines, including chemerin and resistin compared with controls matched by age, sex and body mass index.
  •  A reduction of these serum adipokines is observed in patients treated with infliximab.

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