P. Gisondi, V. Lora, C. Bonauguri, A. Russo, G. Lippi and G. Girolomoni Serum chemerin is increased in patients with chronic plaque psoriasis and normalizes following treatment with infliximab British Journal of Dermatology 168
What’s already known about this topic?
Chronic plaque psoriasis is frequently associated with obesity, which is a metabolic and inflammatory disorder.
Adipokines are involved in the pathogenesis of psoriasis and they are biomarkers of obesity-related inflammation and cardiovascular risk.
Chemerin is pathogenetically expressed in psoriatic lesional skin.
What does this study add?
Patients with psoriasis have higher blood levels of adipokines, including chemerin and resistin compared with controls matched by age, sex and body mass index.
A reduction of these serum adipokines is observed in patients treated with infliximab.
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