K. Ross-Hansen, A. Linneberg, J.D. Johansen, L.-G. Hersoug, C. Brasch-Andersen, T. Menné and J.P. Thyssen The role of glutathione S-transferase and claudin-1 gene polymorphisms in contact sensitization: a cross-sectional study British Journal of Dermatology 168
What’s already known about this topic?
Polymorphisms in the gene encoding the tight-junction protein claudin (CLDN)-1 were recently associated with atopic dermatitis.
Polymorphisms in the glutathione S-transferase (GST) genes have been associated with contact sensitization, but their role remains unclear.
What does this study add?
CLDN1 polymorphisms may affect the propensity to develop contact sensitization to common haptens.
Polymorphisms in the GST genes do not seem to be of importance in contact sensitization when assessed in a general population.
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