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K. Ross-Hansen, A. Linneberg, J.D. Johansen, L.-G. Hersoug, C. Brasch-Andersen, T. Menné and J.P. Thyssen The role of glutathione S-transferase and claudin-1 gene polymorphisms in contact sensitization: a cross-sectional study British Journal of Dermatology 168

Version of Record online: 31 JAN 2013 | DOI: 10.1111/bjd.12126

What’s already known about this topic?

  •  Polymorphisms in the gene encoding the tight-junction protein claudin (CLDN)-1 were recently associated with atopic dermatitis.
  •  Polymorphisms in the glutathione S-transferase (GST) genes have been associated with contact sensitization, but their role remains unclear.

What does this study add?

  • CLDN1 polymorphisms may affect the propensity to develop contact sensitization to common haptens.
  •  Polymorphisms in the GST genes do not seem to be of importance in contact sensitization when assessed in a general population.

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