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S.B. Cho, Z. Zheng, K.J. Ahn, M.J. Choi, S. Cho, D.-Y. Kim, H.S. Lee and D. Bang Serum IgA reactivity against GroEL of Streptococcus sanguinis and human heterogeneous nuclear ribonucleoprotein A2/B1 in patients with Behçet disease British Journal of Dermatology 168

Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12128

What’s already known about this topic?

  •  Infectious agents, especially Streptococcus sanguinis and herpes simplex virus, have long been postulated as major triggering factors for Behçet disease (BD).
  •  Human heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 has been identified as a target antigen of the antiendothelial-cell IgA antibody in patients with BD.

What does this study add?

  •  Chaperonin GroEL was identified as a target antigen of the antiendothelial-cell IgA antibody in patients with BD.
  •  Serum IgA reactivities against recombinant S. sanguinis GroEL and human hnRNP A2/B1 were significantly correlated.
  •  Among the eight distinctive epitopes with significant homology between S. sanguinis GroEL and human hnRNP A2/B1, serum IgA reactivity of patients with BD was particularly strong with epitopes 3 and 6.

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