S.B. Cho, Z. Zheng, K.J. Ahn, M.J. Choi, S. Cho, D.-Y. Kim, H.S. Lee and D. Bang Serum IgA reactivity against GroEL of Streptococcus sanguinis and human heterogeneous nuclear ribonucleoprotein A2/B1 in patients with Behçet disease British Journal of Dermatology 168
What’s already known about this topic?
Infectious agents, especially Streptococcus sanguinis and herpes simplex virus, have long been postulated as major triggering factors for Behçet disease (BD).
Human heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 has been identified as a target antigen of the antiendothelial-cell IgA antibody in patients with BD.
What does this study add?
Chaperonin GroEL was identified as a target antigen of the antiendothelial-cell IgA antibody in patients with BD.
Serum IgA reactivities against recombinant S. sanguinis GroEL and human hnRNP A2/B1 were significantly correlated.
Among the eight distinctive epitopes with significant homology between S. sanguinis GroEL and human hnRNP A2/B1, serum IgA reactivity of patients with BD was particularly strong with epitopes 3 and 6.
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