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S. Lipowicz, P. Sekula, S. Ingen-Housz-Oro, Y. Liss, B. Sassolas, A. Dunant, J.-C. Roujeau and M. Mockenhaupt Prognosis of generalized bullous fixed drug eruption: comparison with Stevens–Johnson syndrome and toxic epidermal necrolysis British Journal of Dermatology 168

Article first published online: 16 FEB 2013 | DOI: 10.1111/bjd.12133

What’s already known about this topic?

  •  Generalized bullous fixed drug eruption (GBFDE) is a rare variant of FDE.
  •  It is often confused with toxic epidermal necrolysis (TEN) and is considered less severe than TEN.

What does this study add?

  •  Comparison of GBFDE cases with Stevens–Johnson syndrome (SJS) or SJS/TEN cases matched for age and extent of skin detachment was carried out.
  •  The mortality rate was slightly but not significantly lower for GBFDE than for cases of SJS or SJS/TEN.
  •  The reputation of the benign nature of GBFDE should be reconsidered.

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