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H.E. Teulings, E.P.M. Tjin, K.J. Willemsen, G. Krebbers, C.J. van Noesel, E.H. Kemp, L. Nieuweboer-Krobotova, J.P.W. van der Veen and R.M. Luiten Radiation-induced melanoma-associated leucoderma, systemic antimelanoma immunity and disease-free survival in a patient with advanced-stage melanoma: a case report and immunological analysis British Journal of Dermatology 168

Version of Record online: 27 FEB 2013 | DOI: 10.1111/bjd.12136

What’s already known about this topic?

  •  Melanoma-associated leucoderma (MAL) can occur in patients with melanoma.
  •  MAL is mostly seen upon immunotherapy and is associated with favourable clinical outcome.
  •  Although melanoma is considered a radioresistant tumour, radiotherapy may have a beneficial effect as an adjuvant therapy.

What does this study add?

  •  This is the first case report of MAL development upon radiotherapy in a long term surviving melanoma patient with brain metastasis, who did not receive any immunotherapy.
  •  Radiotherapy may induce specific antimelanoma immunity and thereby act as a form of immunotherapy.
  •  T cells are able to infiltrate brain metastasis tissue, possibly contributing to the ongoing full remission of the patient.

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