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W. Xie, H. Xie, F. Liu, W. Li, J. Dan, Y. Mei, L. Dan, X. Xiao, J. Li and X. Chen Propranolol induces apoptosis of human umbilical vein endothelial cells through downregulation of CD147 British Journal of Dermatology 168

Version of Record online: 25 MAR 2013 | DOI: 10.1111/bjd.12193

What’s already known about this topic?

  •  Propranolol is the most promising therapy for complicated infantile haemangiomas (IHs).
  •  Beta blockade induces apoptosis in cultured capillary endothelial cells, and the rate of apoptosis increases during the involution phase.

What does this study add?

  •  Our studies demonstrate that propranolol-induced apoptosis may be mediated through the downregulation of CD147 in human umbilical vein endothelial cells.
  •  This study highlights a novel step in propranolol action and suggests a new potential target for the treatment of IHs.

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