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D. Gonzalez, L. Fearfield, P. Nathan, P. Tanière, A. Wallace, E. Brown, C. Harwood, J. Marsden and S. Whittaker BRAF mutation testing algorithm for vemurafenib treatment in melanoma: recommendations from an expert panel British Journal of Dermatology 168

Article first published online: 25 MAR 2013 | DOI: 10.1111/bjd.12248

What’s already known about this topic?

  •  Mutations in the BRAF gene have been identified as key drivers of melanoma cells and are found in around 50% of cutaneous melanomas.
  •  Vemurafenib (Zelboraf®) is the first licensed inhibitor of mutated BRAF and offers a new first-line option for patients with unresectable or metastatic melanoma who harbour BRAF mutations.
  •  Vemurafenib was developed in conjunction with a companion diagnostic, the cobas® 4800 BRAF V600 Mutation Test.

What does this study add?

  •  Evidence-based recommendations to facilitate the implementation of BRAF mutation testing and targeted therapy in patients with metastatic melanoma in the U.K.

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