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Y. Ji, S. Chen, K. Li, X. Xiao, T. Xu and S. Zheng Upregulated autocrine vascular endothelial growth factor (VEGF)/VEGF receptor-2 loop prevents apoptosis in haemangioma-derived endothelial cells British Journal of Dermatology 170

Version of Record online: 13 JAN 2014 | DOI: 10.1111/bjd.12592

What's already known about this topic?

  • Haemangioma-derived endothelial cells (HaemECs) exhibit an X-chromosome inactivation pattern of clonality and show upregulation of vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR)-2 signalling pathways.
  • Propranolol induces apoptosis in cultured vascular ECs, including HaemECs.

What does this study add?

  • Compared with ‘normal’ ECs, HaemECs showed increased resistance to apoptosis induced by serum starvation and β-blockers.
  • The upregulated autocrine VEGF/VEGFR-2 loop can induce general resistance to apoptotic stimuli in HaemECs.

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