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M. Saha, B. Bhogal, M.M. Black, D. Cooper, R.W. Vaughan and R.W. Groves Prognostic factors in pemphigus vulgaris and pemphigus foliaceus British Journal of Dermatology 170

Article first published online: 13 JAN 2014 | DOI: 10.1111/bjd.12630

What's already known about this topic?

  • Pemphigus typically has a chronic course, although there is great variability in disease duration and time taken to disease remission between individuals with the disease. The reasons for this are unclear.
  • Certain genetic, epidemiological, clinical and immunological factors may be implicated in prognosis of pemphigus.

What does this study add?

  • This is the first detailed exploration of prognostic factors in both PV and PF in a U.K. population.
  • We have identified that ethnic group, age at presentation, initial intercellular antibody titre and initial desmoglein 3 antibody levels all had a significant impact on prognosis of pemphigus.

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