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A.L. Gerber, A. Münst, C. Schlapbach, M. Shafighi, D. Kiermeir, R. Hüsler and R.E. Hunger High expression of FOXP3 in primary melanoma is associated with tumour progression British Journal of Dermatology 170

Version of Record online: 13 JAN 2014 | DOI: 10.1111/bjd.12641

What's already known about this topic?

  • Breslow tumour thickness is the most important prognostic marker for melanoma.
  • The immune system, and especially regulatory mechanisms, are important for tumour control and tumour progression.
  • The transcription factor forkhead box protein (FOXP)3 is specific for regulatory T cells.

What does this study add?

  • High expression of FOXP3 in the primary melanoma is associated with reduced time to disease progression and reduced overall survival, independent of the tumour thickness.
  • FOXP3 immunohistochemical staining is easy to perform and may be used to detect patients at high risk for tumour progression.

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