Hongzhi Wang, Rui Sun, Hui Lin and Wei-han Hu P16INK4A as a surrogate biomarker for human papillomavirus-associated oropharyngeal carcinoma: Consideration of some aspects Cancer Science 104
Human papillomavirus-associated oropharyngeal carcinomas have been extensively recognized a distinct entity. P16INK4A is evidenced to be a surrogate biomarker of HPV status. However, there is diversity of sensitivity and specificity about p16 in surrogate detection of HPV infection or transactivation. We summarized the current knowledge to explain the discrepancy between p16INK4A expression and HPV infection, and recommended suitable method of HPV status detection for clinical use. In addition, we reviewed the prognosis of p16INK4A or HPV associated entity and pointed out the cautious perspective for deintensified treatment.
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