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Yuji Sato, Masakazu Yashiro and Nobuyuki Takakura Heregulin induces resistance to lapatinib-mediated growth inhibition of HER2-amplified cancer cells Cancer Science 104

Article first published online: 28 OCT 2013 | DOI: 10.1111/cas.12290

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Here, we investigated whether and how HRG1 causes resistance to lapatinib in gastric and gastroesophageal junction cancers in vitro. Exposure to HRG1 together with lapatinib rescued cells from lapatinib-induced cell cycle arrest and apoptosis.

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