Shugo Suzuki, Kazuhide Shiraga, Shinya Sato, Wanisa Punfa, Aya Naiki-Ito, Yoriko Yamashita, Tomoyuki Shirai and Satoru Takahashi Apocynin, an NADPH oxidase inhibitor, suppresses rat prostate carcinogenesis Cancer Science 104
Apocynin, a NADPH oxidase inhibitor, suppressed prostate carcinogenesis in TRAP model with reduction of reactive oxygen species (ROS) generation and cell proliferation in vivo. it also inhibited ROS production and blocked cell growth by inducing G0/G1 arrest with down-regulation of clusterin and cyclin D1 in LNCaP cells. These data suggest that apocynin possesses a chemopreventive potential for prostate cancer.
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