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Dandan Zhang, Yan Wang, Lina Dong, Yangang Huang, Jing Yuan, Wei Ben, Yang Yang, Ning Ning, Meisong Lu and Yongmei Guan Therapeutic role of EF24 targeting glucose transporter 1-mediated metabolism and metastasis in ovarian cancer cells Cancer Science 104

Version of Record online: 12 NOV 2013 | DOI: 10.1111/cas.12293

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We report in this study the inhibition effect of EF24 against the energy metabolism in ovarian cancer cells and tumors through the down-regulation of Glut1 expression. This effect may further lead to the inhibition of cell migration, invasion and tumor metastasis. Therefore, EF24 is likely a possible candidate for anti-metastasis therapeutic applications for ovarian cancer.

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