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Xiao-Song Ge, Hua-Juan Ma, Xiao-Hui Zheng, Hong-Lian Ruan, Xiao-Yu Liao, Wen-Qiong Xue, Yuan-Bin Chen, Ying Zhang and Wei-Hua Jia HOTAIR, a prognostic factor in esophageal squamous cell carcinoma, inhibits WIF-1 expression and activates Wnt pathway Cancer Science 104

Version of Record online: 29 OCT 2013 | DOI: 10.1111/cas.12296

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HOTAIR, a long non coding RNA, has been linked to the progression of several types of human cancer. In this study, we found that HOTAIR was not only significantly up-regulated in tumor tissues, but also significantly associated with poor clinical outcome in patients with esophageal squamous cell carcinoma (ESCC). ESCC cells with HOTAIR overexpression displayed aberrant activated WNT signaling pathway by inhibiting the expression of WNT-inhibitor factor 1, thereby promote the migration and invasion of ESCC cells. On the contrary, silencing of HOTAIR in ESCC cells led to decreased migration and invasion ability. Together, these results suggest that HOTAIR overexpression may serve as a novel prognostic biomarker and potential therapeutic target for the treatment of human ESCC.

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