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Takehiro Suzuki, Satoshi Yamashita, Toshikazu Ushijima, Shota Takumi, Tomoharu Sano, Takehiro Michikawa and Keiko Nohara Genome-wide analysis of DNA methylation changes induced by gestational arsenic exposure in liver tumors Cancer Science 104

Version of Record online: 8 NOV 2013 | DOI: 10.1111/cas.12298

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This study further revealed that the gene body region of the oncogene Fosb is highly methylated and its expression is greatly increased in the tumors of gestationally arsenic-exposed mice in comparison with the tumors of control mice. These results suggest that DNA methylation changes are involved in the alteration in tumor phenotype by gestational arsenic exposure.

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