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Mitsugu Yamamoto, Mitsuchika Hosoda, Kiichiroh Nakano, Shusheng Jia, Kanako C. Hatanaka, Emi Takakuwa, Yutaka Hatanaka, Yoshihiro Matsuno and Hiroko Yamashita p53 accumulation is a strong predictor of recurrence in estrogen receptor-positive breast cancer patients treated with aromatase inhibitors Cancer Science 105

Version of Record online: 22 NOV 2013 | DOI: 10.1111/cas.12302

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Expression of p53, as well as expression of ER, PgR, HER2 and Ki67 by immunohistochemistry were investigated in postmenopausal ER-positive breast cancer patients who were treated with aromatase inhibitors as adjuvant endocrine therapy. Our study demonstrates that p53 accumulation is a strong predictor of both early and late recurrence.

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