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Takayuki Uehara, Takeharu Kanazawa, Hiroaki Mizukami, Ryosuke Uchibori, Tomonori Tsukahara, Masashi Urabe, Akihiro Kume, Kiyoshi Misawa, Thomas E. Carey, Mikio Suzuki, Keiichi Ichimura and Keiya Ozawa Novel anti-tumor mechanism of galanin receptor type 2 in head and neck squamous cell carcinoma cells Cancer Science 105

Version of Record online: 1 DEC 2013 | DOI: 10.1111/cas.12315

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Transduced HEp-2 and KB cell lines using a recombinant adeno-associated virus (rAAV)-GFP vector showed a high GFP expression rate. GALR2 express in the presence of galanin suppressed cell viability in both cell lines. The annexin V-positive rate and sub-G0/G1 phase population were significantly elevated in the both cells. Furthermore, in HEp-2 cells, GALR2-mediated apoptosis was caspase-independent, involving down-regulation of ERK1/2, followed by induction of the pro-apoptotic Bcl-2 protein, Bim.

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