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Naohiro Uraoka, Naohide Oue, Naoya Sakamoto, Kazuhiro Sentani, Htoo Zarni Oo, Yutaka Naito, Tsuyoshi Noguchi and Wataru Yasui NRD1, which encodes nardilysin protein, promotes esophageal cancer cell invasion through induction of MMP2 and MMP3 expression Cancer Science 105

Version of Record online: 29 NOV 2013 | DOI: 10.1111/cas.12316

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Univariate and multivariate analyses revealed that nardilysin expression is an independent prognostic classifier of patients with esophageal squamous cell carcinoma. The invasiveness of NRD1-knockdown TE1 and TE5 esophageal cancer cell lines was less than that of the negative control siRNA-transfected cell lines. These results suggest that nardilysin is involved in tumor progression, and is an independent prognostic classifier in patients with esophageal squamous cell carcinoma.

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