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Momoko Sato, Naoki Muguruma, Tadahiko Nakagawa, Koichi Okamoto, Tetsuo Kimura, Shinji Kitamura, Hiromi Yano, Katsutaka Sannomiya, Takahiro Goji, Hiroshi Miyamoto, Toshiya Okahisa, Hiroaki Mikasa, Satoshi Wada, Masao Iwata and Tetsuji Takayama High antitumor activity of pladienolide B and its derivative in gastric cancer Cancer Science 105

Version of Record online: 4 DEC 2013 | DOI: 10.1111/cas.12317

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The pladienolide B and its derivative showed very high anti-tumor activity against various gastric cancer cell lines and primary cultured gastric cancer cells from carcinomatous ascites in vitro and in a xenograft model. The mechanism of the anti-tumor activity of pladienolide B involves splicing impairment and apoptosis induction.

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