Xiao-Mei Huang, Xiao-Sun Liu, Xian-Ke Lin, Hang Yu, Jian-Yi Sun, Xiao-Kun Liu, Chao Chen, Hai-Long Jin, Ge-Er Zhang, Xiao-Xiao Shi, Qing Zhang and Ji-Ren Yu Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer Cancer Science 105
We found that numbers of pDCs, Tregs and ICOS+ Tregs in peripheral blood were increased in GC patients compared with healthy donors. In tissue, Tregs and ICOS+ Tregs were found distributing mainly in carcinoma tissue, while pDCs mainly in peritumor tissue. Both pDCs and ICOS+ Tregs participate in the immunosuppression microenviroment of gastric cancer together.
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