Jinsong Yang, Haogang Yu, Mo Shen, Wei Wei, Lihong Xia and Peng Zhao N1-guanyl-1,7-diaminoheptane sensitizes bladder cancer cells to doxorubicin by preventing epithelial–mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2 activation Cancer Science 105
Doxorubicin-induced EMT reduced the chemotherapeutic effect of doxorubicin treatment in bladder cancer cells. GC7, which inhibited activity of eIF5A2, sensitized bladder cancer cells to doxorubicin via preventing EMT. Combined treatment of GC7 and doxorubicin provides a new insight to clinic bladder cancer therapy.
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